Effects of sub-chronic combined treatment with pergolide and caffeine on contralateral rotational behavior in unilateral 6-hydroxydopamine-denervated rats

Brain Res. 2000 Jun 23;868(2):376-9. doi: 10.1016/s0006-8993(00)02361-1.

Abstract

We studied the synergistic effects of pergolide and bromocriptine with caffeine on turning behavior in 6-OHDA denervated rats. Both pergolide and bromocriptine were synergistic with caffeine, and prevented tolerance to caffeine-induced turning. When caffeine was removed, tolerance to bromocriptine effects was observed for 1 day only, while no tolerance was observed to pergolide. These results suggest that caffeine could be useful in the treatment of Parkinson's disease, preferentially as an adjuvant of mixed dopaminergic agonists like pergolide.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bromocriptine / pharmacology
  • Caffeine / pharmacology*
  • Denervation
  • Drug Administration Schedule
  • Drug Combinations
  • Drug Tolerance / physiology*
  • Male
  • Motor Activity / drug effects*
  • Motor Activity / physiology*
  • Oxidopamine / pharmacology
  • Parkinsonian Disorders / drug therapy*
  • Parkinsonian Disorders / pathology
  • Parkinsonian Disorders / physiopathology
  • Pergolide / pharmacology*
  • Rats
  • Rats, Sprague-Dawley
  • Rotation*

Substances

  • Drug Combinations
  • Pergolide
  • Bromocriptine
  • Caffeine
  • Oxidopamine