Abstract
Chemokine mRNA expression by pulmonary leukocytes following infection of BALB/c mice with two strains of respiratory syncytial virus (RSV) and one strain of parainfluenza virus type 3 (PIV-3) was determined. The results suggest that RSV G and/or SH proteins inhibit early MIP-1alpha, MIP-1beta, MIP-2, MCP-1, and IP-10 mRNA expression. TCA-3 mRNA expression was found to be increased during PIV-3 infection.
MeSH terms
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Animals
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Chemokine CCL1
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Chemokine CCL2 / genetics
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Chemokine CCL3
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Chemokine CCL4
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Chemokine CCL5 / genetics
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Chemokine CXCL10
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Chemokine CXCL2
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Chemokines, CC / genetics*
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Chemokines, CXC / genetics*
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Cytokines / genetics
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Female
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Gene Expression Regulation
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Glycoproteins / genetics
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Glycoproteins / metabolism*
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HN Protein*
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Macrophage Inflammatory Proteins / genetics
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Mice
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Mice, Inbred BALB C
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Monokines / genetics
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Parainfluenza Virus 3, Human / metabolism
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Parainfluenza Virus 3, Human / physiology
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RNA, Messenger*
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Receptors, CCR8
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Respiratory Syncytial Virus, Human / genetics
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Respiratory Syncytial Virus, Human / metabolism*
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Viral Envelope Proteins
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Viral Proteins / genetics
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Viral Proteins / metabolism*
Substances
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CCL1 protein, human
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Ccr8 protein, mouse
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Chemokine CCL1
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Chemokine CCL2
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Chemokine CCL3
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Chemokine CCL4
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Chemokine CCL5
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Chemokine CXCL10
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Chemokine CXCL2
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Chemokines, CC
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Chemokines, CXC
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Cytokines
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Glycoproteins
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HN Protein
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Macrophage Inflammatory Proteins
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Monokines
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RNA, Messenger
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Receptors, CCR8
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Viral Envelope Proteins
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Viral Proteins
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attachment protein G