Alcohol consumption and cigarette smoking in relation to high frequency of p53 protein accumulation in oesophageal squamous cell carcinoma in the Japanese

H Saeki; S Ohno; K Araki; A Egashira; H Kawaguchi; Y Ikeda; M Morita; K Kitamura; K Sugimachi

doi:10.1054/bjoc.1999.1212

Alcohol consumption and cigarette smoking in relation to high frequency of p53 protein accumulation in oesophageal squamous cell carcinoma in the Japanese

Br J Cancer. 2000 Jun;82(11):1892-4. doi: 10.1054/bjoc.1999.1212.

Authors

H Saeki¹, S Ohno, K Araki, A Egashira, H Kawaguchi, Y Ikeda, M Morita, K Kitamura, K Sugimachi

Affiliation

¹ The Second Department of Surgery, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

Abstract

We investigated levels of p53 protein expression in Japanese patients with oesophageal squamous cell carcinoma. A significantly larger proportion of heavy alcohol drinkers and cigarette smokers was evident in the p53-positive group. The combination of drinking and smoking was associated with a high frequency of p53 protein accumulation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alcohol Drinking / metabolism*
Carcinoma, Squamous Cell / metabolism*
Esophageal Neoplasms / metabolism*
Humans
Immunohistochemistry
Nicotiana
Odds Ratio
Plants, Toxic
Smoking / metabolism*
Tumor Suppressor Protein p53 / metabolism*

Substances

Tumor Suppressor Protein p53