PaaSiCats: novel polyamino acid catalysts

Chirality. 2000 Jun;12(5-6):313-7. doi: 10.1002/(SICI)1520-636X(2000)12:5/6<313::AID-CHIR3>3.0.CO;2-H.

Abstract

The abilities of five polyamino acids (Paa's) to catalyse the asymmetric epoxidation of enones 1-7 under three sets of reaction conditions were compared: polyneo-pentylglycine and polyleucine showed distinct advantages in most circumstances. All five polymers were adsorbed onto silica and from this further study, immobilised polyneo-pentylglycine (PLNSi) and polyleucine (PLLSi) were shown to be the catalysts of choice for the asymmetric epoxidation of less-reactive alpha,beta-unsaturated ketones.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acids / chemistry*
  • Catalysis
  • Chemistry / methods
  • Ketones / chemistry
  • Models, Chemical
  • Oxygen / metabolism
  • Peptides / chemistry
  • Silicon Dioxide / chemistry

Substances

  • Amino Acids
  • Ketones
  • Peptides
  • polyleucine
  • polyglycine
  • Silicon Dioxide
  • Oxygen