[Anti-A antibodies and bacterial contamination of platelet concentrates]

Sangre (Barc). 1999 Dec;44(6):434-7.
[Article in Spanish]

Abstract

Objectives: The possible ABO group antibodies protective function against several infections has been classically described. We analyze the platelet concentrates (PC) bacterial control results and their ABO antibodies.

Material and methods: We studied 245 outdated PCs (> 5 days). The samples were sterilely collected for adequate microbiological investigation studies on sheep-blood agar plates. If bacterial growth is found, the microbiological identification is performed on the basis of standard tests, the specific anti-biotype being achieved by disk-diffusion method on Müeller-Hinton agar plates, and the red cell concentrate was analyzed.

Results: Bacterial growth by negative coagulase Staphylococcus was found in 10 PCs (4.1%; CI95%; 1.97-7.37). The contaminated PCs lacked natural anti-A antibodies. There were no statistical differences when we analyzed the PC's age, colour or blood group.

Comments: The anti-A antibodies may be a protective factor versus PCs contamination caused by resident bacteria.

Publication types

  • English Abstract

MeSH terms

  • ABO Blood-Group System / immunology*
  • Blood Bactericidal Activity / immunology*
  • Blood Platelets / microbiology*
  • Coagulase / metabolism
  • Humans
  • In Vitro Techniques

Substances

  • ABO Blood-Group System
  • Coagulase