Total synthesis of (-)-reveromycin B

Org Lett. 2000 Jan 27;2(2):191-4. doi: 10.1021/ol991281m.

Abstract

[structure: see text] The total synthesis of the epidermal growth factor inhibitor reveromycin B (2) is described. A novel, convergent, and stereoselective reaction sequence was utilized to construct the 5,6-spiroketal system 10 which was converted into the natural product 2 by a 16-step sequence.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemical synthesis*
  • Epidermal Growth Factor / antagonists & inhibitors
  • Pyrans / chemical synthesis*
  • Spiro Compounds / chemical synthesis*
  • Stereoisomerism

Substances

  • Antineoplastic Agents
  • Pyrans
  • Spiro Compounds
  • reveromycin B
  • Epidermal Growth Factor