Radical cyclization of sugar-derived beta-(alkynyloxy)acrylates: synthesis of novel fused ethers

Org Lett. 2000 May 4;2(9):1275-7. doi: 10.1021/ol0000408.

Abstract

[formula: see text] Tributyltin radical mediated cyclization of carbohydrate-derived beta-(alkynyloxy)acrylates leading to highly functionalized cis- and trans-fused bicyclic ethers of various ring sizes is described. The efficacy of the radical cyclization is nicely illustrated in the iterative construction of a trans-fused tricyclic tetrahydropyran.