Amplification of the ABC transporter gene PGPA and increased trypanothione levels in potassium antimonyl tartrate (SbIII) resistant Leishmania tarentolae

Mol Biochem Parasitol. 2000 Apr 30;108(1):131-5. doi: 10.1016/s0166-6851(00)00187-0.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • ATP-Binding Cassette Transporters / genetics*
  • Animals
  • Antimony Potassium Tartrate / pharmacology*
  • Antiprotozoal Agents / pharmacology*
  • Arsenites / pharmacology
  • Drug Resistance / genetics
  • Gene Amplification
  • Genes, Protozoan
  • Glutathione / analogs & derivatives*
  • Glutathione / metabolism
  • Leishmania / drug effects*
  • Leishmania / genetics*
  • Leishmania / metabolism
  • Membrane Glycoproteins / genetics*
  • Protozoan Proteins*
  • Spermidine / analogs & derivatives*
  • Spermidine / metabolism

Substances

  • ATP-Binding Cassette Transporters
  • Antiprotozoal Agents
  • Arsenites
  • Membrane Glycoproteins
  • PgpA protein, Leishmania
  • Protozoan Proteins
  • trypanothione
  • Antimony Potassium Tartrate
  • Glutathione
  • arsenite
  • Spermidine