Toxicity of ALS-linked SOD1 mutants

Science. 2000 Apr 21;288(5465):399. doi: 10.1126/science.288.5465.399a.
No abstract available

MeSH terms

  • Amyotrophic Lateral Sclerosis / enzymology*
  • Amyotrophic Lateral Sclerosis / genetics
  • Amyotrophic Lateral Sclerosis / pathology
  • Animals
  • Apoptosis
  • Cells, Cultured
  • Copper / metabolism
  • Humans
  • Mice
  • Motor Neurons / metabolism
  • Motor Neurons / pathology*
  • Mutation
  • Neurofilament Proteins / metabolism
  • Nitrates / metabolism
  • Superoxide Dismutase / genetics*
  • Superoxide Dismutase / metabolism*
  • Superoxide Dismutase-1
  • Yeasts / cytology
  • Yeasts / metabolism
  • Zinc / metabolism*
  • Zinc / toxicity

Substances

  • Neurofilament Proteins
  • Nitrates
  • SOD1 protein, human
  • peroxynitric acid
  • Copper
  • Sod1 protein, mouse
  • Superoxide Dismutase
  • Superoxide Dismutase-1
  • Zinc