Imipenem but not meropenem induces convulsions in DBA/2 mice, unrelated to cerebrospinal fluid concentrations

Fundam Clin Pharmacol. 2000 Mar-Apr;14(2):163-5. doi: 10.1111/j.1472-8206.2000.tb00406.x.

Abstract

Imipenem and meropenem CSF diffusion was comparable in DBA/2 mice but only imipenem induced convulsions, not related to CSF concentration.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cilastatin / pharmacology
  • Dose-Response Relationship, Drug
  • Imipenem / cerebrospinal fluid
  • Imipenem / pharmacology*
  • Infusions, Intravenous
  • Male
  • Meropenem
  • Mice
  • Mice, Inbred DBA
  • Protease Inhibitors / pharmacology
  • Rats
  • Seizures / chemically induced*
  • Thienamycins / cerebrospinal fluid
  • Thienamycins / pharmacology*

Substances

  • Protease Inhibitors
  • Thienamycins
  • Cilastatin
  • Imipenem
  • Meropenem