Abstract
The effects of an endogenous indole, isatin (indole-2, 3-dione), on the hyperthermia induced by atrial natriuretic peptide (ANP-28), brain natriuretic peptide (BNP-32), and C-type natriuretic peptide (CNP-22) were investigated in rats. Intracerebroventricular administration of each peptide in a dose of 1 microg caused elevations in colon temperature 30 and 60 min after injection. An intraperitoneal (i.p.) injection of isatin (50 mg/kg) abolished the natriuretic peptide-induced hyperthermia. These data reinforce the possible involvement of natriuretic peptides in thermoregulatory processes in the central nervous system, and suggest that isatin might counteract their hyperthermic effect in vivo.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Analysis of Variance
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Animals
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Atrial Natriuretic Factor / administration & dosage
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Atrial Natriuretic Factor / antagonists & inhibitors
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Atrial Natriuretic Factor / pharmacology*
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Body Temperature / drug effects
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Cerebral Ventricles / drug effects
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Cerebral Ventricles / physiology*
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Fever / chemically induced
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Fever / prevention & control*
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Injections, Intraperitoneal
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Injections, Intraventricular
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Isatin / administration & dosage
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Isatin / pharmacology*
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Male
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Natriuretic Peptide, Brain*
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Natriuretic Peptide, C-Type / administration & dosage
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Natriuretic Peptide, C-Type / pharmacology*
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Nerve Tissue Proteins / administration & dosage
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Nerve Tissue Proteins / pharmacology*
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Rats
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Rats, Wistar
Substances
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Nerve Tissue Proteins
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Natriuretic Peptide, Brain
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brain natriuretic peptide, porcine
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Natriuretic Peptide, C-Type
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Isatin
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Atrial Natriuretic Factor