[Absence of cross resistance between an irinotecan plus cisplatin combination and raltitrexed (ZD1694) in two patients with advanced colorectal cancer]

Gan To Kagaku Ryoho. 2000 Apr;27(4):617-21.
[Article in Japanese]

Abstract

Two patients with advanced colorectal cancer were consecutively administered two different chemotherapeutic regimens. The first patient showed an initial response to combination treatment with irinotecan plus cisplatin, but then progressed. He subsequently responded to treatment with a novel thymidylate synthase (TS) inhibitor, raltitrexed. The second patient, who progressed after exhibiting a response to raltitrexed, subsequently responded to irinotecan/cisplatin combination therapy. In conclusion, no clinical cross resistance between the regimens of irinotecan/cisplatin combination therapy and raltitrexed was observed in these patients with advanced colorectal cancer.

Publication types

  • Case Reports

MeSH terms

  • Antimetabolites, Antineoplastic / administration & dosage*
  • Antineoplastic Agents / administration & dosage*
  • Antineoplastic Agents, Phytogenic / administration & dosage*
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Camptothecin / administration & dosage
  • Camptothecin / analogs & derivatives*
  • Cisplatin / administration & dosage*
  • Colorectal Neoplasms / drug therapy*
  • Drug Resistance
  • Enzyme Inhibitors / administration & dosage*
  • Female
  • Humans
  • Irinotecan
  • Male
  • Middle Aged
  • Quinazolines / administration & dosage*
  • Thiophenes / administration & dosage*
  • Thymidylate Synthase / antagonists & inhibitors*

Substances

  • Antimetabolites, Antineoplastic
  • Antineoplastic Agents
  • Antineoplastic Agents, Phytogenic
  • Enzyme Inhibitors
  • Quinazolines
  • Thiophenes
  • Irinotecan
  • Thymidylate Synthase
  • raltitrexed
  • Cisplatin
  • Camptothecin