The subfamily alphaherpesuvirinae contains herpes simplex virus(HSV) and varicella-zoster virus(VZV) in the Dermatology. HSV infectious diseases are herpetic gingivostomatitis, herpes labialis, facial herpes simplex, Kaposi's varicelliform eruption, genital herpes, lumbosacral herpes simplex, and herpetic whitlow. The primary form of VZV infection is varicella, and the reactivation form is herpes zoster. These infectious diseases in the dermatological clinics usually occur in adult. In this paper we mention clinical manifestations and treatment.