Coronary artery disease is responsible for approximately 75-80% of sudden cardiac deaths in most industrialized countries. Risk factors can be divided in those which suggest structural heart disease and those reflecting abnormal physiological markers. Therapeutic strategies for primary prevention of sudden cardiac death require careful scrutiny. The systematic use of risk markers to identify and stratify high risk groups may be of help to establish primary prevention measures in daily practice. Different methods to stratify risk factors using ejection fraction, ventricular arrhythmias, heart rate variability, baroreflex sensitivity, and dispersion of repolarization are discussed in this article.