A polymorphic tetranucleotide repeat in the CYP19 gene and male breast cancer

I E Young; K M Kurian; M A MacKenzie; I H Kunkler; B B Cohen; M L Hooper; A H Wyllie; C M Steel

doi:10.1054/bjoc.1999.1085

A polymorphic tetranucleotide repeat in the CYP19 gene and male breast cancer

Br J Cancer. 2000 Apr;82(7):1247-8. doi: 10.1054/bjoc.1999.1085.

Authors

I E Young¹, K M Kurian, M A MacKenzie, I H Kunkler, B B Cohen, M L Hooper, A H Wyllie, C M Steel

Affiliation

¹ University of Edinburgh, Department of Pathology, Molecular Medicine Centre, Western General Hospital, UK.

Abstract

The CYP19 gene codes for the aromatase enzyme that is involved in the synthesis of oestrogens. This case-control study examines the relationship between a tetranucleotide repeat sequence in the CYP19 gene and the development of male breast cancer. No significant differences were found between male breast cancer cases and controls.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aromatase / genetics*
Breast Neoplasms, Male / genetics*
Case-Control Studies
Genetic Predisposition to Disease
Humans
Male
Microsatellite Repeats / genetics*
Polymerase Chain Reaction

Substances

Aromatase