Alpha(2) adrenoceptor agonists as potential analgesic agents. 2. Discovery of 4-(4-imidazo)-1,3-dimethyl-6,7-dihydro-thianaphthene as a high-affinity ligand for the alpha(2D) adrenergic receptor

J Med Chem. 2000 Apr 6;43(7):1423-6. doi: 10.1021/jm000128r.
No abstract available

Publication types

  • Corrected and Republished Article

MeSH terms

  • Adrenergic alpha-Agonists / chemical synthesis*
  • Adrenergic alpha-Agonists / chemistry
  • Adrenergic alpha-Agonists / pharmacology
  • Analgesics / chemical synthesis
  • Analgesics / chemistry
  • Analgesics / pharmacology
  • Animals
  • Binding, Competitive
  • Cell Line
  • Humans
  • Imidazoles / chemical synthesis*
  • Imidazoles / chemistry
  • Imidazoles / pharmacology
  • Ligands
  • Mice
  • Pain Measurement
  • Radioligand Assay
  • Rats
  • Receptors, Adrenergic, alpha-2 / drug effects*
  • Receptors, Adrenergic, alpha-2 / metabolism
  • Structure-Activity Relationship
  • Thiophenes / chemical synthesis*
  • Thiophenes / chemistry
  • Thiophenes / pharmacology

Substances

  • Adrenergic alpha-Agonists
  • Analgesics
  • Imidazoles
  • Ligands
  • RWJ 52353
  • Receptors, Adrenergic, alpha-2
  • Thiophenes