Turning a corner on HIV neutralization?

J H Nunberg; K E Follis; M Trahey; R A LaCasse

doi:10.1016/s1286-4579(00)00267-7

Turning a corner on HIV neutralization?

Microbes Infect. 2000 Feb;2(2):213-21. doi: 10.1016/s1286-4579(00)00267-7.

Authors

J H Nunberg¹, K E Follis, M Trahey, R A LaCasse

Affiliation

¹ Montana Biotechnology Center, The University of Montana, Missoula, MT 59812, USA.

PMID: 10742693
DOI: 10.1016/s1286-4579(00)00267-7

Abstract

HIV vaccine development has been hampered by the inability of conventional immunogens to elicit antibodies capable of neutralizing primary isolates of the virus. Recent studies using 'fusion-competent' immunogens that capture transitional intermediate structures of the functioning envelope protein suggest that this goal may now be achievable.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

AIDS Vaccines / immunology*
Animals
HIV / immunology*
HIV Envelope Protein gp120 / immunology
HIV Infections / prevention & control*
Humans
Neutralization Tests
Peptide Fragments / immunology
Vaccines, Synthetic / immunology*

Substances

AIDS Vaccines
HIV Envelope Protein gp120
HIV envelope protein gp120 (305-321)
Peptide Fragments
Vaccines, Synthetic