Pyrrolo[3,2-c]pyridine derivatives as inhibitors of platelet aggregation

C Altomare; L Summo; S Cellamare; A V Varlamov; L G Voskressensky; T N Borisova; A Carotti

doi:10.1016/s0960-894x(00)00052-4

Pyrrolo[3,2-c]pyridine derivatives as inhibitors of platelet aggregation

Bioorg Med Chem Lett. 2000 Mar 20;10(6):581-4. doi: 10.1016/s0960-894x(00)00052-4.

Authors

C Altomare¹, L Summo, S Cellamare, A V Varlamov, L G Voskressensky, T N Borisova, A Carotti

Affiliation

¹ Dipartimento Farmacochimico, Università degli Studi, Bari, Italy. altomare@farmchim.uniba.it

PMID: 10741558
DOI: 10.1016/s0960-894x(00)00052-4

Abstract

A series of pyrrolo[3,2-c]pyridines, isosteres of the antithrombotic drug ticlopidine, has been synthesized and evaluated in vitro for the ability to inhibit aggregation of human platelet-rich plasma induced by adenosin 5'-diphosphate (ADP). Structure-activity relationships showed their antiplatelet effects to be related to the lipophilicity.

MeSH terms

Adenosine Diphosphate / antagonists & inhibitors
Adenosine Diphosphate / pharmacology
Chemical Phenomena
Chemistry, Physical
Chromatography, High Pressure Liquid
Humans
In Vitro Techniques
Lipids / chemistry
Platelet Aggregation / drug effects
Platelet Aggregation Inhibitors / chemical synthesis*
Platelet Aggregation Inhibitors / pharmacology
Pyridines / chemical synthesis*
Pyridines / pharmacology
Pyrroles / chemical synthesis*
Pyrroles / pharmacology
Structure-Activity Relationship
Ticlopidine / pharmacology

Substances

Lipids
Platelet Aggregation Inhibitors
Pyridines
Pyrroles
Adenosine Diphosphate
Ticlopidine