Trisomy 5 as a sole cytogenetic abnormality in pediatric acute lymphoblastic leukemia

C Sandoval; S P Mayer; M F Ozkaynak; O Tugal; S Jayabose

doi:10.1016/s0165-4608(99)00176-4

Trisomy 5 as a sole cytogenetic abnormality in pediatric acute lymphoblastic leukemia

Cancer Genet Cytogenet. 2000 Apr 1;118(1):69-71. doi: 10.1016/s0165-4608(99)00176-4.

Authors

C Sandoval¹, S P Mayer, M F Ozkaynak, O Tugal, S Jayabose

Affiliation

¹ Department of Pediatrics, New York Medical College, Valhalla, NY 10595, USA.

PMID: 10731595
DOI: 10.1016/s0165-4608(99)00176-4

Abstract

We describe a case of pediatric acute lymphoblastic leukemia (ALL) with trisomy 5 as a sole cytogenetic abnormality. A comparison is made with the two cases of adult acute lymphoblastic leukemia with trisomy 5 in the literature. This rare cytogenetic abnormality may portend an especially poor prognosis in patients with ALL.

Publication types

Case Reports
Review

MeSH terms

Adult
Child
Chromosomes, Human, Pair 5 / genetics*
Fatal Outcome
Female
Gene Rearrangement, B-Lymphocyte / genetics
Gene Rearrangement, delta-Chain T-Cell Antigen Receptor
Genes, Immunoglobulin / genetics
Humans
Male
Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis
Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / mortality
Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology
Prognosis
Trisomy / genetics*