Arthrogryposis multiplex congenita and bilateral mid-brain infarction following maternal overdose of co-proxamol

Eur J Paediatr Neurol. 1997;1(5-6):183-6. doi: 10.1016/s1090-3798(97)80056-6.

Abstract

We report a case of arthrogryposis multiplex congenita secondary to fetal hypokinesia in a 41-week gestation infant following antenatal central nervous system injury. The mother's pregnancy was complicated by an episode of attempted self harm, with an overdose of co-proxamol at 22 weeks of gestational age, and by the use of cocaine in combination with excess alcohol intake. Magnetic resonance imaging showed bilateral mid-brain cysts and marked atrophy of the basal ganglia and thalami.

Publication types

  • Case Reports

MeSH terms

  • Acetaminophen / poisoning*
  • Arthrogryposis / chemically induced*
  • Arthrogryposis / diagnosis
  • Brain / pathology
  • Brain Damage, Chronic / chemically induced
  • Brain Damage, Chronic / diagnosis
  • Cocaine-Related Disorders / diagnosis
  • Dextropropoxyphene / poisoning*
  • Drug Combinations
  • Drug Overdose / diagnosis*
  • Female
  • Fetal Alcohol Spectrum Disorders / diagnosis
  • Fetal Movement / drug effects
  • Humans
  • Infant, Newborn
  • Magnetic Resonance Imaging
  • Male
  • Pregnancy
  • Pregnancy Complications / diagnosis*
  • Suicide, Attempted*

Substances

  • Drug Combinations
  • Acetaminophen
  • acetaminophen, dextropropoxyphene, drug combination
  • Dextropropoxyphene