New paralytic alkaloids, asperparalines A, B and C, from Aspergillus japonicus JV-23

Biosci Biotechnol Biochem. 2000 Jan;64(1):111-5. doi: 10.1271/bbb.64.111.

Abstract

New paralytic alkaloids, asperparalines A (1), B (2) and C (3), were isolated from okara (the insoluble residue of whole soybean) that had been fermented with Aspergillus japonicus JV-23. Their structures were elucidated by spectroscopic methods and X-ray crystallography. These asperparalines showed paralytic activity against silk worms.

MeSH terms

  • Alkaloids / analysis*
  • Animals
  • Aspergillus / chemistry*
  • Bombyx / drug effects
  • Crystallography, X-Ray
  • Fermentation
  • Glycine max
  • Larva / drug effects
  • Models, Chemical
  • Models, Molecular
  • Paralysis / chemically induced
  • Piperazines*
  • Protein Conformation
  • Spiro Compounds*

Substances

  • Alkaloids
  • Piperazines
  • Spiro Compounds
  • aspergillimide
  • asperparaline B
  • asperparaline C