Interferon-alpha-associated development of bullous lesions in mycosis fungoides

Dermatology. 2000;200(1):51-3. doi: 10.1159/000018317.

Abstract

We report a 67-year-old woman with mycosis fungoides (MF) who was receiving subcutaneous injections of recombinant interferon alpha-2b (IFN-alpha). After 2 months of IFN-alpha treatment, bullous lesions appeared on her trunk and extremities. A skin biopsy specimen from the trunk revealed histopathologic features of bullous MF. Bullous lesions with specific infiltrates of MF are very rare; to the best of our knowledge, this is the first case showing specific bullous lesions of MF developed under IFN-alpha treatment.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antineoplastic Agents / adverse effects*
  • Antineoplastic Agents / therapeutic use
  • Female
  • Humans
  • Interferon Type I / adverse effects*
  • Interferon Type I / therapeutic use
  • Mycosis Fungoides / drug therapy*
  • Recombinant Proteins
  • Skin Diseases, Vesiculobullous / chemically induced*
  • Skin Neoplasms / drug therapy*

Substances

  • Antineoplastic Agents
  • Interferon Type I
  • Recombinant Proteins