Protein folding: Thickening the broth

Curr Biol. 2000 Feb 10;10(3):R97-9. doi: 10.1016/s0960-9822(00)00301-8.

Abstract

Recent results support the notion that macromolecular 'crowding' enhances protein aggregation, at the expense of correct folding. The results can be rationalised in terms of kinetic competition between distinct processes, taking into account the relative influence of crowding on each process.

MeSH terms

  • Macromolecular Substances
  • Protein Folding*
  • Protein Renaturation*
  • Proteins / chemistry*

Substances

  • Macromolecular Substances
  • Proteins