Three different types of operation were performed in 31 osteosarcoma patients, and some cases received chemotherapy. It revealed, wide resection of tumor supplemented with chemotherapy improved the survival and limb salvage rate enormously. Chemotherapy and wide resection were all absolutely essential. The life of prosthesis was long and most patients were satisfied with it. Chemotherapy and limb salvage can enhance the survival and life quality in patients with osteosarcoma.