Proton-resonance frequency shift MR thermometry is affected by changes in the electrical conductivity of tissue

Magn Reson Med. 2000 Jan;43(1):62-71. doi: 10.1002/(sici)1522-2594(200001)43:1<62::aid-mrm8>3.0.co;2-1.

Abstract

The proton-resonance frequency (PRF) shift method of MR thermometry provides an easy and practical means of quantitatively monitoring in vivo temperatures for MR image-guided thermal-coagulation therapy. However, reported discrepancies in the numerical value of the PRF-thermal coefficient persist, when measured in a variety of experimental conditions and in different tissue types, both ex vivo and in vivo. In this report, a potential source of variation in the PRF-shift method of thermometry is identified that manifests as a constant incremental phase shift per unit change in temperature that is independent of the echo-time setting, when constructing temperature-sensitive phase images from a gradient-echo pulse sequence. It is proposed that this confounding phase-shift offset arises from thermally induced changes in the electrical conductivity of the material. To this end, it is demonstrated that the MR-derived temperature changes could be in error by as much as 28%, as measured from a simple calibration experiment on freshly excised cow liver. A simple method of overcoming this phase-shift offset is described.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Artifacts
  • Cattle
  • Culture Techniques
  • Electric Conductivity
  • Electromagnetic Fields*
  • Hot Temperature*
  • Hyperthermia, Induced*
  • Liver / pathology
  • Liver / physiology*
  • Magnetic Resonance Imaging*
  • Models, Biological*
  • Phantoms, Imaging
  • Thermometers