Few issues prepare women to cope with the multitude of problems that confront them when diagnosed with breast cancer. The provision of appropriate treatment requires that health care professionals attend to the emotional, social, and other nonmedical functioning of the woman and her family. Nurse practitioners play a central role in the delivery of medical care. This article describes the typical response of women to breast cancer and factors associated with risk for the development of comorbid psychological and adjustment problems. Pragmatic suggestions to guide nurse practitioners in assisting patients and their families cope with breast cancer are provided, as well as indicators for referral to a mental health professional.