Distal tubular dysfunction in lupus nephritis of childhood and adolescence

Pediatr Nephrol. 1999 Nov;13(9):846-9. doi: 10.1007/s004670050713.

Abstract

We describe a girl with lupus nephritis who presented with distal renal tubular acidosis and hyporeninemic hypoaldosteronism. While distal tubular dysfunction is well recognized in adult systemic lupus erythematosus (SLE), only a few pediatric patients have been reported. Evaluation of five pediatric patients with SLE revealed that distal tubular dysfunction in childhood and adolescence is rare.

Publication types

  • Case Reports

MeSH terms

  • Acidosis, Renal Tubular / blood
  • Acidosis, Renal Tubular / complications*
  • Acidosis, Renal Tubular / pathology
  • Adolescent
  • Aldosterone / blood
  • Child
  • Creatinine / blood
  • Female
  • Furosemide / metabolism
  • Humans
  • Hydrogen-Ion Concentration
  • Hypoaldosteronism / blood
  • Hypoaldosteronism / complications*
  • Hypoaldosteronism / pathology
  • Kidney / ultrastructure
  • Lupus Nephritis / blood
  • Lupus Nephritis / complications*
  • Lupus Nephritis / pathology
  • Microscopy, Electron
  • Potassium / blood
  • Renin / blood

Substances

  • Aldosterone
  • Furosemide
  • Creatinine
  • Renin
  • Potassium