Gram-negative bacterial sepsis and the sepsis syndrome

Urol Clin North Am. 1999 Nov;26(4):687-99. doi: 10.1016/s0094-0143(05)70211-1.

Abstract

Gram-negative sepsis syndrome is an increasingly common complication in medical and surgical patients. The molecular and cellular mechanisms underlying this dreaded complication are yielding to investigation. These studies have led to a multiplicity of targets for novel therapies. Despite highly promising results in many animal studies, clinical studies have been disappointing.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Gram-Negative Bacterial Infections* / diagnosis
  • Gram-Negative Bacterial Infections* / metabolism
  • Gram-Negative Bacterial Infections* / physiopathology
  • Gram-Negative Bacterial Infections* / therapy
  • Humans
  • Systemic Inflammatory Response Syndrome / diagnosis
  • Systemic Inflammatory Response Syndrome / metabolism
  • Systemic Inflammatory Response Syndrome / microbiology*
  • Systemic Inflammatory Response Syndrome / physiopathology
  • Systemic Inflammatory Response Syndrome / therapy*
  • Urinary Tract Infections / diagnosis
  • Urinary Tract Infections / metabolism
  • Urinary Tract Infections / microbiology*
  • Urinary Tract Infections / physiopathology
  • Urinary Tract Infections / therapy*