Abstract
At present, little is known about the pathogenesis of acute virus-induced shock and pulmonary failure. A chief impediment in understanding the underlying disease mechanisms and developing treatment strategies has been the lack of a suitable animal model. This study describes a mouse model of virus-induced systemic shock and respiratory distress, and shows that blockade of the lymphotoxin beta receptor pathway reverses the disease.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antibodies, Monoclonal / pharmacology
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Disease Models, Animal
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Female
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Humans
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Lymphocytic Choriomeningitis / immunology
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Lymphocytic Choriomeningitis / pathology
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Lymphocytic Choriomeningitis / therapy
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Lymphotoxin beta Receptor
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Male
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Mice
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Mice, Inbred NZB
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Receptors, Tumor Necrosis Factor / antagonists & inhibitors*
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Respiratory Insufficiency / immunology
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Respiratory Insufficiency / pathology
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Respiratory Insufficiency / therapy*
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Shock, Septic / immunology
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Shock, Septic / pathology
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Shock, Septic / therapy*
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Signal Transduction
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Time Factors
Substances
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Antibodies, Monoclonal
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LTBR protein, human
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Ltbr protein, mouse
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Lymphotoxin beta Receptor
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Receptors, Tumor Necrosis Factor