Synthesis and in vitro cytotoxicity of hexacyclic camptothecin analogues

S Jew; H J Kim; M G Kim; E Y Roh; C I Hong; J K Kim; J H Lee; H Lee; H Park

doi:10.1016/s0960-894x(99)00555-7

Synthesis and in vitro cytotoxicity of hexacyclic camptothecin analogues

Bioorg Med Chem Lett. 1999 Nov 15;9(22):3203-6. doi: 10.1016/s0960-894x(99)00555-7.

Authors

S Jew¹, H J Kim, M G Kim, E Y Roh, C I Hong, J K Kim, J H Lee, H Lee, H Park

Affiliation

¹ College of Pharmacy, Seoul National University, Korea.

PMID: 10576688
DOI: 10.1016/s0960-894x(99)00555-7

Abstract

A series of C(7)-N-alkylaminoethyl-C(10), C(11)-methylenedioxy- and ethylenedioxy-camptothecin (3a-g, 4a-b) were prepared. Their syntheses and in vitro cytotoxicity were reported. Among 15 derivatives, 3a and 3b showed more potent cytotoxicity than Camptothecin, especially in CAOV-3 cell line.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / pharmacology*
Camptothecin / analogs & derivatives*
Camptothecin / chemical synthesis
Camptothecin / pharmacology
Drug Screening Assays, Antitumor
Humans
Structure-Activity Relationship
Tumor Cells, Cultured

Substances

Antineoplastic Agents
Camptothecin