The human caspase-activated DNase gene (hCAD): genomic structure, exonic single-nucleotide polymorphisms, and a highly polymorphic dinucleotide repeat at the hCAD locus

N Sugimoto; Y Fukuda; F Saito-Ohara; R Kamiyama; A Nakagawara; N Mukae; S Nagata; J Inazawa

doi:10.1007/s100380050188

The human caspase-activated DNase gene (hCAD): genomic structure, exonic single-nucleotide polymorphisms, and a highly polymorphic dinucleotide repeat at the hCAD locus

J Hum Genet. 1999;44(6):408-11. doi: 10.1007/s100380050188.

Authors

N Sugimoto¹, Y Fukuda, F Saito-Ohara, R Kamiyama, A Nakagawara, N Mukae, S Nagata, J Inazawa

Affiliation

¹ Department of Molecular Cytogenetics, Tokyo Medical and Dental University, Japan.

PMID: 10570914
DOI: 10.1007/s100380050188

Abstract

Caspase-activated DNase (CAD) cleaves chromosomal DNA during apoptosis. We determined its genomic structure and identified single-nucleotide polymorphisms (SNPs) within exons 5 and 7, as well as a highly polymorphic dinucleotide repeat of (CT)m(CA)n within the 5' region of the human CAD gene (hCAD). The genomic structure of hCAD presented here, together with information concerning SNPs within the gene, as well as a highly polymorphic (CT)m(CA)n repeat fragment at the hCAD locus, may assist in the construction of genetic maps for exploring gene(s) that play pivotal roles in carcinogenesis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Deoxyribonucleases / genetics*
Dinucleotide Repeats / genetics*
Exons / genetics
Humans
Polymorphism, Single Nucleotide*

Substances

Deoxyribonucleases
caspase-activated deoxyribonuclease