Effect of theophylline on the warm-up phenomenon

R A Kerensky; E Franco; J D Schlaifer; C J Pepine; L Belardinelli

doi:10.1016/s0002-9149(99)00502-0

Effect of theophylline on the warm-up phenomenon

Am J Cardiol. 1999 Nov 1;84(9):1077-80, A9. doi: 10.1016/s0002-9149(99)00502-0.

Authors

R A Kerensky¹, E Franco, J D Schlaifer, C J Pepine, L Belardinelli

Affiliation

¹ Division of Cardiovascular Medicine, University of Florida, Shands at the University of Florida, Gainesville 32610-0277, USA.

PMID: 10569667
DOI: 10.1016/s0002-9149(99)00502-0

Abstract

This study examined whether the adenosine receptor antagonist theophylline prevents the warm-up phenomenon in patients with stable angina undergoing serial exercise tests. Our findings offer evidence that adenosine does not play a role in the warm-up phenomenon, and indirectly suggest that the warm-up phenomenon does not represent ischemic preconditioning in humans.

Publication types

Clinical Trial
Randomized Controlled Trial

MeSH terms

Adenosine / physiology*
Adult
Aged
Angina Pectoris / physiopathology*
Coronary Angiography / drug effects
Coronary Disease / physiopathology
Cross-Over Studies
Double-Blind Method
Electrocardiography / drug effects
Exercise Test / drug effects*
Female
Humans
Infusions, Intravenous
Ischemic Preconditioning, Myocardial*
Male
Middle Aged
Purinergic P1 Receptor Antagonists*
Theophylline / pharmacology*

Substances

Purinergic P1 Receptor Antagonists
Theophylline
Adenosine