Facile, Novel Methodology for the Synthesis of Spiro

Angew Chem Int Ed Engl. 1999 Nov 2;38(21):3186-3189.

Abstract

The role of the bifunctional catalyst is decisive: The magnesium ion as Lewis acid and its nucleophilic iodide counterion contribute in synergy to the successful ring expansion of the cyclopropane 1 by aldimine 2 [Eq. (1)]. This reaction offers a novel route to spiro[pyrrolidin-3,3'-oxindoles] 3.