Effect of bradykinin on prostaglandin synthetase activity in microsomal fractions from rat duodenum and uterus

Acta Biol Med Ger. 1978;37(5-6):901-3.

Abstract

The bioconversion of tritiated arachidonic acid by microsomal fractions from rat uterus and duodenum is described. In rat duodenum the formation of both prostaglandin E2 and F2alpha is enhanced by the peptide hormone bradykinin. In contrast, bradykinin inhibits the synthesis of PGE2 in rat uterus.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Bradykinin / pharmacology*
  • Duodenum / enzymology*
  • Female
  • Microsomes / drug effects
  • Microsomes / enzymology*
  • Organ Specificity
  • Prostaglandin-Endoperoxide Synthases / metabolism*
  • Prostaglandins E / biosynthesis
  • Prostaglandins F / biosynthesis
  • Rats
  • Uterus / enzymology*

Substances

  • Prostaglandins E
  • Prostaglandins F
  • Prostaglandin-Endoperoxide Synthases
  • Bradykinin