Cerebral vasoreactivity to arterial carbon dioxide tension in preterm infants: the effect of ibuprofen

J Pediatr. 1999 Nov;135(5):644-6. doi: 10.1016/s0022-3476(99)70065-x.

Abstract

Cerebral vasoreactivity to CO(2), calculated by linear regression of total cerebral hemoglobin, measured by near infrared spectroscopy, and corresponding PaCO(2), in infants <32 weeks' gestation, was found to be unaffected by the administration of ibuprofen, which was given on the first postnatal day as prophylaxis against patent ductus arteriosus.

MeSH terms

  • Brain / blood supply
  • Carbon Dioxide / blood*
  • Cerebrovascular Circulation / drug effects*
  • Ductus Arteriosus, Patent / prevention & control*
  • Hemoglobins / metabolism
  • Humans
  • Ibuprofen / therapeutic use*
  • Infant, Newborn
  • Infant, Premature, Diseases / prevention & control*
  • Spectroscopy, Near-Infrared

Substances

  • Hemoglobins
  • Carbon Dioxide
  • Ibuprofen