Abstract
Lipid bilayer experiments indicated that the cell wall of Mycobacterium tuberculosis contains at least two different porins: (i) a cation-selective, heat-sensitive 0.7-nS channel which has a short-lived open state and is probably composed of 15-kDa subunits and (ii) a 3-nS, >60-kDa channel with a long-lived open state, resembling porins from fast-growing mycobacteria.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Cations, Monovalent / metabolism
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Cell Compartmentation
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Cell Wall / chemistry*
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Cell Wall / metabolism
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Diffusion
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Electric Conductivity
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Ion Channel Gating
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Liposomes
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Mycobacterium tuberculosis / chemistry*
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Mycobacterium tuberculosis / metabolism
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Porins / isolation & purification*
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Porins / metabolism
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Protein Structure, Quaternary
Substances
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Cations, Monovalent
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Liposomes
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Porins
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mspA protein, Mycobacterium smegmatis