Two new cytotoxic carbonimidic dichlorides from the nudibranch Reticulidia fungia

J Tanaka; T Higa

doi:10.1021/np990186j

Two new cytotoxic carbonimidic dichlorides from the nudibranch Reticulidia fungia

J Nat Prod. 1999 Sep;62(9):1339-40. doi: 10.1021/np990186j.

Authors

J Tanaka¹, T Higa

Affiliation

¹ Department of Chemistry, Biology, and Marine Science, University of the Ryukyus, Nishihara, Okinawa 903-0213, Japan. jtanaka@sci-u.ryukyu.ac.jp

PMID: 10514331
DOI: 10.1021/np990186j

Abstract

Two new sesquiterpenes, reticulidins A (1) and B (2), containing a rare functional group, N=CCl(2), have been isolated together with known congeners from the nudibranch Reticulidia fungia and their structures elucidated by spectroscopic data. Both 1 and 2 were cytotoxic against KB and L1210 cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Drug Screening Assays, Antitumor
Humans
Imides / chemistry
Imides / isolation & purification*
Imides / pharmacology
Molecular Structure
Mollusca / chemistry*
Spectrum Analysis
Tumor Cells, Cultured

Substances

Imides
reticulidia A
reticulidia B