3D QSAR studies on new oxazolidinone antibacterial agents by comparative molecular field analysis

Bioorg Med Chem Lett. 1999 Sep 20;9(18):2685-90. doi: 10.1016/s0960-894x(99)00474-6.

Abstract

Three-dimensional QSAR studies for two series of new oxazolidinone antibacterial agents were conducted using the comparative molecular field analysis (CoMFA). In vitro activities (MICs) of the compounds against methicillin-resistant Staphylococcus aureus 88 (MRSA 88) exhibited a strong correlation with their steric, electrostatic factors and lipophilicities.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemistry*
  • Anti-Bacterial Agents / pharmacology*
  • Microbial Sensitivity Tests
  • Oxazoles / chemistry*
  • Oxazoles / pharmacology*
  • Staphylococcus aureus / drug effects*
  • Structure-Activity Relationship

Substances

  • Anti-Bacterial Agents
  • Oxazoles