Radioprotective effects of sodium tungstate on hematopoietic injury by exposure to 60Co gamma-rays in Wistar rats

J Radiat Res. 1999 Jun;40(2):101-13. doi: 10.1269/jrr.40.101.

Abstract

Radioprotective effects of sodium tungstate (ST) on 60Co gamma-ray induced decrease in hematocrit value and in survival rate in Wistar strain male rats were examined. A long-term administration of ST (less than 150 mg/kg body weight/day) for 60-300 days had no significant effects on body and organs weights and survival days. The LD50/60 in 20 weeks old rats was 220 mg/kg body weight/day. Daily administration of 38, 75 or 150 mg from 7 days before and after irradiation to 60 days significantly mitigated the decrease in hematocrit values, especially at 23 days after irradiation (P < 0.05). The highest mitigation rate of the decrease in hematocrit value was observed in rats administered at a dose of 38 mg ST/day. Simultaneously, a dose of 38 mg ST/day inhibited lethal effect of 60Co gamma-rays significantly. The dose-reduction factor for survival of 38 mg ST administered rats was 1.14.

MeSH terms

  • Animals
  • Body Weight / drug effects
  • Body Weight / radiation effects
  • Cobalt Radioisotopes
  • Gamma Rays / adverse effects
  • Hematocrit
  • Hematopoiesis / drug effects*
  • Hematopoiesis / radiation effects*
  • Male
  • Organ Size / drug effects
  • Organ Size / radiation effects
  • Radiation Injuries, Experimental / prevention & control
  • Radiation Tolerance / drug effects
  • Radiation-Protective Agents / pharmacology*
  • Rats
  • Rats, Wistar
  • Tungsten Compounds / pharmacology*

Substances

  • Cobalt Radioisotopes
  • Radiation-Protective Agents
  • Tungsten Compounds
  • sodium tungstate(VI)