The use of timing behaviors in animals and humans to detect drug and/or toxicant effects

Neurotoxicol Teratol. 1999 Sep-Oct;21(5):491-502. doi: 10.1016/s0892-0362(99)00015-x.

Abstract

Behavioral paradigms applicable for use in both human and nonhuman subjects for investigating aspects of timing behavior are presented with a view towards exploring their strengths, weaknesses, and utility in a variety of experimental situations. Tri-peak, peak interval, differential reinforcement of low rate responding, and temporal response differentiation procedures are highlighted. In addition, the application of timing tasks in preclinical and clinical settings is discussed: pharmacological manipulations are providing information on the neurotransmitters involved and species differences; normative data for children are being developed; and noninvasive imaging procedures are being employed in adult human subjects to explore the involvement of specific brain areas.

Publication types

  • Congress

MeSH terms

  • Animals
  • Behavior / drug effects*
  • Behavior, Animal / drug effects*
  • Drug-Related Side Effects and Adverse Reactions
  • Humans
  • Reaction Time / drug effects
  • Time Perception / drug effects*
  • Toxicity Tests