2-5A-PNA complexes: a novel class of antisense compounds

J C Verheijen; S F Bayly; M R Player; P F Torrence; G A van der Marel; J H van Boom

doi:10.1080/07328319908044761

2-5A-PNA complexes: a novel class of antisense compounds

Nucleosides Nucleotides. 1999 Jun-Jul;18(6-7):1485-6. doi: 10.1080/07328319908044761.

Authors

J C Verheijen¹, S F Bayly, M R Player, P F Torrence, G A van der Marel, J H van Boom

Affiliation

¹ Leiden Institute of Chemistry, The Netherlands.

PMID: 10474229
DOI: 10.1080/07328319908044761

Abstract

This paper presents the fully automated solid phase synthesis of 2-5A-PNA hybrids. These stable antisense probes cause RNase L mediated hydrolysis of target RNA sequences.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Base Sequence
Endoribonucleases / chemistry
Hydrolysis
Oligonucleotides, Antisense / chemistry*
Peptide Nucleic Acids / chemistry*

Substances

Oligonucleotides, Antisense
Peptide Nucleic Acids
Endoribonucleases
2-5A-dependent ribonuclease