Ubiquitin pathway: another link in the polyubiquitin chain?

Curr Biol. 1999;9(15):R554-7. doi: 10.1016/s0960-9822(99)80353-4.

Abstract

Polyubiquitin has long been recognised as an intracellular signal. It now appears that different lysine linkages between the ubiquitin moieties are recognised as distinct signals and act in different cell processes. The generation of these different polyubiquitin chains may play an important part in the life of a cell.

Publication types

  • Review

MeSH terms

  • Animals
  • Biopolymers / chemistry
  • Biopolymers / genetics
  • Biopolymers / metabolism*
  • Ligases / metabolism
  • Lysine / chemistry
  • Mutagenesis, Site-Directed
  • Peptide Hydrolases / metabolism
  • Polyubiquitin
  • Proteasome Endopeptidase Complex*
  • Signal Transduction
  • Ubiquitin-Conjugating Enzymes
  • Ubiquitin-Protein Ligases
  • Ubiquitins / chemistry
  • Ubiquitins / genetics
  • Ubiquitins / metabolism*

Substances

  • Biopolymers
  • Ubiquitins
  • Polyubiquitin
  • Ubiquitin-Conjugating Enzymes
  • Ubiquitin-Protein Ligases
  • Peptide Hydrolases
  • Proteasome Endopeptidase Complex
  • ATP dependent 26S protease
  • Ligases
  • Lysine