'Feeling the pressure': structural insights into a gated mechanosensitive channel

Curr Opin Struct Biol. 1999 Aug;9(4):448-54. doi: 10.1016/S0959-440X(99)80063-3.

Abstract

The structure determination of the large-conductance mechanosensitive channel (MscL) from Mycobacterium tuberculosis has revealed the architecture of the first full-length, gated pentameric ion channel. This structure provides insights into the elements participating in the conductance and gating mechanisms of these channels.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Amino Acid Sequence
  • Bacteria / metabolism
  • Bacterial Proteins / chemistry*
  • Bacterial Proteins / physiology
  • Crystallography, X-Ray
  • Escherichia coli Proteins*
  • Ion Channel Gating / physiology*
  • Ion Channels / chemistry*
  • Ion Channels / physiology
  • Ion Transport
  • Models, Molecular
  • Molecular Sequence Data
  • Mycobacterium tuberculosis / metabolism
  • Pressure
  • Protein Conformation
  • Protein Structure, Secondary
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Stress, Mechanical

Substances

  • Bacterial Proteins
  • Escherichia coli Proteins
  • Ion Channels
  • MscL protein, E coli