Abstract
The in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin were tested against 72 ciprofloxacin-resistant and 28 ciprofloxacin-susceptible isolates of Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes. Irrespective of the alterations in GyrA and ParC proteins, clinafloxacin exhibited greater activity than all other fluoroquinolones tested against K. pneumoniae and E. aerogenes.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Infective Agents / pharmacology*
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Aza Compounds*
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Ciprofloxacin / pharmacology
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DNA Gyrase
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DNA Topoisomerase IV
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DNA Topoisomerases, Type II / genetics*
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DNA Topoisomerases, Type II / physiology
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Enterobacter cloacae / drug effects*
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Enterobacter cloacae / genetics
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Enterobacter cloacae / isolation & purification
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Fluoroquinolones*
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Gatifloxacin
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Humans
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Klebsiella pneumoniae / drug effects
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Klebsiella pneumoniae / genetics*
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Klebsiella pneumoniae / isolation & purification
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Levofloxacin
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Microbial Sensitivity Tests
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Molecular Sequence Data
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Moxifloxacin
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Naphthyridines / pharmacology
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Ofloxacin / pharmacology
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Quinolines*
Substances
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Anti-Infective Agents
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Aza Compounds
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Fluoroquinolones
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Naphthyridines
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Quinolines
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Ciprofloxacin
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Levofloxacin
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clinafloxacin
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trovafloxacin
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Ofloxacin
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DNA Topoisomerase IV
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DNA Gyrase
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DNA Topoisomerases, Type II
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Gatifloxacin
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Moxifloxacin