Hyperthermic effect of centrally administered natriuretic peptides in the rat

Peptides. 1999;20(2):193-7. doi: 10.1016/s0196-9781(98)00173-9.

Abstract

The effects of atrial natriuretic peptide (ANP-28), brain natriuretic peptide (BNP-32) and C-type natriuretic peptide (CNP-22) on body temperature were investigated in rats. Intracerebroventricular administration of each peptide in doses of 400 or 1000 ng caused a dose-related elevation in colon temperature 30 and 60 min after injection. A 40 ng dose of ANP-28 was also hyperthermic at 60 min. An intramuscular (i.m.) injection of noraminophenazone (a cyclooxygenase inhibitor) abolished the natriuretic peptide-induced hyperthermia. The results show that natriuretic peptides may participate in thermoregulatory processes in the central nervous system, and that their hyperthermic effect may be mediated via a cyclooxygenase-involved pathway.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Atrial Natriuretic Factor / pharmacology*
  • Body Temperature / drug effects*
  • Colon / drug effects
  • Cyclooxygenase Inhibitors / pharmacology
  • Dipyrone / analogs & derivatives
  • Dose-Response Relationship, Drug
  • Fever / chemically induced*
  • Injections, Intraventricular
  • Male
  • Natriuretic Peptide, Brain*
  • Natriuretic Peptide, C-Type / pharmacology*
  • Nerve Tissue Proteins / pharmacology*
  • Pyrazolones*
  • Rats
  • Rats, Wistar

Substances

  • Cyclooxygenase Inhibitors
  • Nerve Tissue Proteins
  • Pyrazolones
  • Natriuretic Peptide, Brain
  • brain natriuretic peptide, porcine
  • Natriuretic Peptide, C-Type
  • Dipyrone
  • Atrial Natriuretic Factor
  • noramidopyrine