Chromatin remodeling and leukemia: new therapeutic paradigms

Blood. 1999 Jul 15;94(2):417-28.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Acetylation
  • Antineoplastic Agents / therapeutic use
  • Cell Differentiation / drug effects
  • Chromatin / metabolism*
  • Chromatin / ultrastructure
  • Chromosomal Proteins, Non-Histone / physiology
  • Core Binding Factor Alpha 2 Subunit
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / physiology
  • Enzyme Inhibitors / therapeutic use
  • Gene Expression Regulation, Leukemic*
  • Histone Deacetylase Inhibitors
  • Histone-Lysine N-Methyltransferase
  • Histones / chemistry
  • Histones / physiology
  • Humans
  • Leukemia / genetics*
  • Leukemia / metabolism
  • Leukemia, Promyelocytic, Acute / drug therapy
  • Leukemia, Promyelocytic, Acute / genetics
  • Leukemia, Promyelocytic, Acute / metabolism
  • Models, Genetic
  • Myeloid-Lymphoid Leukemia Protein
  • Neoplasm Proteins / physiology
  • Nucleic Acid Conformation
  • Nucleosomes / ultrastructure
  • Oncogene Proteins, Fusion / physiology
  • Protein Processing, Post-Translational
  • Proto-Oncogenes*
  • RUNX1 Translocation Partner 1 Protein
  • Recombinant Fusion Proteins / physiology
  • Static Electricity
  • Transcription Factors / physiology
  • Translocation, Genetic
  • Tretinoin / pharmacology
  • Tretinoin / therapeutic use

Substances

  • AML1-ETO fusion protein, human
  • Antineoplastic Agents
  • Chromatin
  • Chromosomal Proteins, Non-Histone
  • Core Binding Factor Alpha 2 Subunit
  • DNA-Binding Proteins
  • Enzyme Inhibitors
  • Histone Deacetylase Inhibitors
  • Histones
  • KMT2A protein, human
  • Neoplasm Proteins
  • Nucleosomes
  • Oncogene Proteins, Fusion
  • PLZF-RARalpha fusion protein, human
  • RUNX1 Translocation Partner 1 Protein
  • Recombinant Fusion Proteins
  • Transcription Factors
  • promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein
  • Myeloid-Lymphoid Leukemia Protein
  • Tretinoin
  • Histone-Lysine N-Methyltransferase