With an understanding of the pathophysiology of ACS and an increasing number of early therapeutic options, there has been a shift in focus from ruling-out MI to identifying and stratifying risk in all patients with potential ACS. The presenting symptoms and ECG still remain the cornerstone of immediate diagnosis and triage. Through the application of new technologies, such as the cardiac troponins, and a reassessment of techniques, such as perfusion imaging and echocardiography, the clinician has an increasing selection of methods to rapidly assess chest pain of potential ischemic etiology. Coinciding with the evaluation of technology has been the development of the concept of the CPU and associated rapid diagnostic protocols. These protocols, whether they utilize the assistance of mathematic predictive instruments or represent simple triage schemes, form the backbone of a system to improve the care of patients with ACS in the current milieu of cost containment.