CD4(+) T cells which react to the Leishmania major LACK antigen rapidly secrete interleukin-4 and are detrimental to the host in resistant B10.D2 mice

V Julia; N Glaichenhaus

doi:10.1128/IAI.67.7.3641-3644.1999

CD4(+) T cells which react to the Leishmania major LACK antigen rapidly secrete interleukin-4 and are detrimental to the host in resistant B10.D2 mice

Infect Immun. 1999 Jul;67(7):3641-4. doi: 10.1128/IAI.67.7.3641-3644.1999.

Authors

V Julia¹, N Glaichenhaus

Affiliation

¹ Institut de Pharmacologie Moléculaire et Cellulaire, 06560 Valbonne, France.

Abstract

Leishmania major induces the rapid production of interleukin-4 (IL-4) in both susceptible BALB/c and resistant B10.D2 mice. In both strains, IL-4 is produced by T cells which react to the parasite LACK (for Leishmania homolog of the receptor for activated C kinase) antigen. The rapid production of IL-4 in B10.D2 mice does not confer susceptibility but results in increased parasite burdens.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antigens, Protozoan / immunology
CD4-Positive T-Lymphocytes / immunology*
Immunity, Innate*
Interleukin-4 / immunology*
Interleukin-4 / metabolism
Leishmania major / immunology*
Leishmaniasis, Cutaneous / immunology*
Mice
Protozoan Proteins / immunology*

Substances

Antigens, Protozoan
Protozoan Proteins
LACK antigen, Leishmania
Interleukin-4