Enhancement of activity-dependent calcium increase by neurotrophin-4 in visual cortex pyramidal neurons

Brain Res. 1999 Jun 19;832(1-2):179-83. doi: 10.1016/s0006-8993(99)01474-2.

Abstract

In pyramidal neurons from rat visual cortex slices, bath-application of NT-4 (20 ng/ml) did not much affected the baseline calcium signal, but did enhance calcium signals elicited by injections of depolarizing currents (+0.5 nA, 1 s). This enhancing effect of NT-4 was abolished by co-applying K252a. With ryanodine injected intracellularly, the effect of NT-4 was significantly reduced, suggesting an involvement of intracellular calcium release in this NT-4-induced enhancement of calcium transient.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Calcium / metabolism*
  • Membrane Potentials / drug effects
  • Nerve Growth Factors / pharmacology*
  • Neuroprotective Agents / pharmacology*
  • Pyramidal Cells / drug effects*
  • Pyramidal Cells / metabolism
  • Rats
  • Rats, Wistar
  • Signal Transduction / drug effects
  • Visual Cortex / cytology
  • Visual Cortex / drug effects*
  • Visual Cortex / metabolism

Substances

  • Nerve Growth Factors
  • Neuroprotective Agents
  • neurotrophin 4
  • Calcium