Possible relationship between conditions associated with chronic hypoxia and brain mitochondrial DNA deletions; reduction of genomic 8-hydroxyguanine levels in human brain tissues containing elevated levels of the human mitochondrial DNA4977 deletion

Arch Biochem Biophys. 1999 Jul 1;367(1):140-2. doi: 10.1006/abbi.1999.1224.
No abstract available

MeSH terms

  • Brain / metabolism*
  • Brain / pathology
  • Chronic Disease
  • DNA Adducts / analysis
  • DNA Adducts / genetics
  • DNA Damage / genetics
  • DNA, Mitochondrial / genetics*
  • Deoxyguanine Nucleotides / analysis
  • Genome, Human*
  • Guanine / analogs & derivatives*
  • Guanine / analysis
  • Humans
  • Hypoxia / metabolism*
  • Mitochondria / genetics
  • Mitochondria / physiology
  • Reactive Oxygen Species / metabolism
  • Sequence Deletion*
  • Statistics as Topic

Substances

  • DNA Adducts
  • DNA, Mitochondrial
  • Deoxyguanine Nucleotides
  • Reactive Oxygen Species
  • 8-hydroxyguanine
  • Guanine